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AIN in AHI Study

Tue 27 Feb 2018 การวิจัยทางคลีนิก

Title: Anal HPV Infection and risk for Anal high-grade Squamous Intraepithelial Lesion among Thai men who have sex with men (MSM) with Acute HIV Infection. Status: Ongoing

What is AIN in AHI?
AIN in AHI is a study to determine the prevalence and incidence of anal high-grade squamous intraepithelial lesion and associated risk factors among MSM who initiate antiretroviral therapy (ART) during acute HIV infection (AHI).

Who is participating in AIN in AHI?
AIN in AHI will enroll 100 MSM with acute HIV infection, ages 18 and older. The participants will be enrolled for 144 weeks, with the total of 8 follow-up visits.

Why is AIN in AHI important?
HPV infection with multiple HPV types is more common in HIV-positive than HIV-negative MSM. Persistent anal HPV infection is also an important risk factor for the development of anal cancer. Previous study at the TRCARC demonstrated high rates of HPV infection and anal HSIL among Thai MSM. However, it was not clear whether the high rates are due to HIV infection or that the use of ART has an effect on anal HPV infection. For this cohort study, we hope that early HIV diagnosis and early ART initiation will mitigate immunological and virological factors that increase HPV persistence and lower anal HSIL incidence.

*The project is in collaboration with SEARCH and sponsored by amfAR TREAT Asia.